The role of arbutin
- Dec 14, 2018 -

Anti-inflammatory, antibacterial effect

Bearberry leaves have anti-inflammatory and antibacterial effects and have traditionally been used to treat urinary tract infections, of which arbutin is its main medicinal ingredient.

 

Antitussive, expectorant, asthma

The administration of arbutin can increase the tracheal secretion of animals, prolong the incubation period of ammonia, cough, reduce the number of coughs, and increase the amount of tracheal phenol red excretion. But so far, its anti-inflammatory, antitussive and expectorative mechanisms have not been reported.

 

Whitening to remove pigmentation

Melanin is a kind of dark pigment substance that causes skin coloration and is produced by a series of biochemical reactions such as oxidation of phenylalanine or tyrosine in melanocytes. Tyrosinase has both tyrosine hydroxylase activity (catalyzing tyrosine→dopa) and dopa oxidase activity (catalyzing dopa→dopa), which is a key factor in the synthesis of melanin by melanocytes. Arbutin can quickly penetrate into the skin, and it can effectively inhibit the activity of tyrosinase in the skin and block the production of melanin without affecting the cell proliferation concentration. It directly binds to tyrosinase, competes with the binding site of dopa, accelerates the decomposition and excretion of melanin, thereby reducing skin pigmentation.

 

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